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  • Radbruch, A. et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat. Rev. Immunol. 6, 741–750 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jarvis, M. F. & Khakh, B. S. ATP-gated P2X cation-channels. Neuropharmacology 56, 208–215 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Borges da Silva, H. et al. The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8(+) T cells. Nature 559, 264–268 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Burnstock, G. P2X ion channel receptors and inflammation. Purinergic Signal. 12, 59–67 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ishikawa, M. et al. Pannexin 3 functions as an ER Ca(2+) channel, hemichannel and gap junction to promote osteoblast differentiation. J. Cell Biol. 193, 1257–1274 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ishikawa, M. et al. Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns. J. Cell Sci. 129, 1018–1030 (2016).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wilmore, J. R., Jones, D. D. & Allman, D. Protocol for improved resolution of plasma cell subpopulations by flow cytometry. Eur. J. Immunol. 47, 1386–1388 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jones, D. D. et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J. Clin. Invest. 126, 4250–4261 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cassese, G. et al. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J. Immunol. 171, 1684–1690 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Burnstock, G. Purine and pyrimidine receptors. Cell. Mol. Life Sci. 64, 1471–1483 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hohenegger, M. et al. Gsalpha-selective G protein antagonists. Proc. Natl Acad. Sci. USA 95, 346–351 (1998).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jones, C. A. et al. Functional characterization of the P2X(4) receptor orthologues. Br. J. Pharmacol. 129, 388–394 (2000).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Heng, T. S., Painter, M. W. & The Immunological Genome Project Consortium. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091–1094 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tabula Sapiens Consortium. The tabula sapiens: a multiple-organ, single-cell transcriptomic atlas of humans. Science 376, eabl4896 (2022).

    Article 

    Google Scholar 

  • Hobeika, E. et al. Testing gene function early in the B cell lineage in mb1-cre mice. Proc. Natl Acad. Sci. USA 103, 13789–13794 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Khalil, A. M., Cambier, J. C. & Shlomchik, M. J. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science 336, 1178–1181 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ahuja, A., Anderson, S. M., Khalil, A. & Shlomchik, M. J. Maintenance of the plasma cell pool is independent of memory B cells. Proc. Natl Acad. Sci. USA 105, 4802–4807 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yannoutsos, N. et al. A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat. Immunol. 5, 443–450 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hoyer, B. F. et al. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J. Exp. Med. 199, 1577–1584 (2004).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Morris, S. C., Cheek, R. L., Cohen, P. L. & Eisenberg, R. A. Autoantibodies in chronic graft versus host result from cognate T–B interactions. J. Exp. Med. 171, 503–517 (1990).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Koshimizu, T. A. et al. Characterization of calcium signaling by purinergic receptor-channels expressed in excitable cells. Mol. Pharmacol. 58, 936–945 (2000).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bettigole, S. E. & Glimcher, L. H. Endoplasmic reticulum stress in immunity. Annu. Rev. Immunol. 33, 107–138 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Han, J. et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat. Cell Biol. 15, 481–490 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Puthalakath, H. et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129, 1337–1349 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wilmore, J. R. & Allman, D. Here, there and anywhere? Arguments for and against the physical plasma cell survival niche. J. Immunol. 199, 839–845 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Robinson, M. J. et al. Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan. Immunity 56, 1596–1612 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Benson, M. J. et al. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J. Immunol. 180, 3655–3659 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • O’Connor, B. P. et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 199, 91–98 (2004).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Peperzak, V. et al. Mcl-1 is essential for the survival of plasma cells. Nat. Immunol. 14, 290–297 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nikbakht, N., Migone, T. S., Ward, C. P. & Manser, T. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments. J. Immunol. 187, 37–46 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Vincent, F. B., Saulep-Easton, D., Figgett, W. A., Fairfax, K. A. & Mackay, F. The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev. 24, 203–215 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228–232 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Suurvali, J., Boudinot, P., Kanellopoulos, J. & Ruutel Boudinot, S. P2X4: a fast and sensitive purinergic receptor. Biomed. J. 40, 245–256 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fujisaki, J. et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 474, 216–219 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Glatman Zaretsky, A. et al. T regulatory cells support plasma cell populations in the bone marrow. Cell Rep. 18, 1906–1916 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zinszner, H. et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12, 982–995 (1998).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tellier, J. et al. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response. Nat. Immunol. 17, 323–330 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Slifka, M. K., Antia, R., Whitmire, J. K. & Ahmed, R. Humoral immunity due to long-lived plasma cells. Immunity 8, 363–372 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Raje, N. et al. Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma. N. Engl. J. Med. 380, 1726–1737 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Seckinger, A. et al. Target expression, generation, preclinical activity and pharmacokinetics of the BCMA-T cell bispecific antibody EM801 for multiple myeloma treatment. Cancer Cell 31, 396–410 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Neubert, K. et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat. Med. 14, 748–755 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Obeng, E. A. et al. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107, 4907–4916 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Woodle, E. S., Tremblay, S. & Driscoll, J. Targeting plasma cells with proteasome inhibitors: principles from primates. J. Am. Soc. Nephrol. 28, 1951–1953 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cheng, Q. et al. Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies. Eur. J. Immunol. 50, 284–291 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ralevic, V. & Burnstock, G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 413–492 (1998).

    CAS 
    PubMed 

    Google Scholar 

  • Iwamoto, T. et al. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. J. Biol. Chem. 285, 18948–18958 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888–1902 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lopez, R., Regier, J., Cole, M. B., Jordan, M. I. & Yosef, N. Deep generative modeling for single-cell transcriptomics. Nat. Methods 15, 1053–1058 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Traag, V. A., Waltman, L. & van Eck, N. J. From Louvain to Leiden: guaranteeing well-connected communities. Sci. Rep. 9, 5233 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 



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