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Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a mouse model with constant p53 expression in its liver cells, the team observed increased numbers of hepatic progenitor cells (HPCs) and liver cancer incidence. These HPCs could induce cancer when injected into certain mice. This did not occur with p53 deleted, demonstrating its critical significance.



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