Bowness, P. HLA-B27. Annu. Rev. Immunol. 33, 29–48 (2015).
Google Scholar
Faham, M. et al. Discovery of T cell receptor beta motifs specific to HLA-B27-positive ankylosing spondylitis by deep repertoire sequence analysis. Arthritis Rheumatol. 69, 774–784 (2017).
Google Scholar
Hanson, A. L. et al. Altered repertoire diversity and disease-associated clonal expansions revealed by T cell receptor immunosequencing in ankylosing spondylitis patients. Arthritis Rheumatol. 72, 1289–1302 (2020).
Google Scholar
Komech, E. A. et al. CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients. Rheumatology 57, 1097–1104 (2018).
Google Scholar
Schlosstein, L. et al. High association of an HL-A antigen, W27, with ankylosing spondylitis. N. Engl. J. Med. 288, 704–706 (1973).
Google Scholar
Brewerton, D. A. et al. Acute anterior uveitis and HL-A 27. Lancet 302, 994–996 (1973).
Google Scholar
Brewerton, D. A. et al. Reiter’s disease and HL-A 27. Lancet 302, 996–998 (1973).
Google Scholar
Rosenbaum, J. T. & Asquith, M. The microbiome and HLA-B27-associated acute anterior uveitis. Nat. Rev. Rheumatol. 14, 704–713 (2018).
Google Scholar
Robinson, P. C. et al. Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis. Arthritis Rheumatol. 67, 149–151 (2015).
Google Scholar
Finch, M. et al. Epidemic Reiter’s syndrome following an outbreak of shigellosis. Eur. J. Epidemiol. 2, 26–30 (1986).
Google Scholar
Aho, K. et al. HL-A 27 in reactive arthritis. A study of yersinia arthritis and Reiter’s disease. Arthritis Rheumatol. 17, 521–526 (1974).
Google Scholar
Benjamin, R. & Parham, P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol. Today 11, 137–142 (1991).
Google Scholar
Hammer, R. E. et al. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63, 1099–1112 (1990).
Google Scholar
Tran, T. M. et al. Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheumatol. 54, 1317–1327 (2006).
Google Scholar
Baggia, S. et al. A novel model of bacterially-induced acute anterior uveitis in rats and the lack of effect from HLA-B27 expression. J. Investig. Med. 45, 295–301 (1997).
Google Scholar
Allen, R. L. et al. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. J. Immunol. 1, 5045–5048 (1999).
DeLay, M. L. et al. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheumatol. 60, 2633–2643 (2009).
Google Scholar
Kollnberger, S. et al. Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheumatol. 46, 2972–2982 (2002).
Google Scholar
Bowness, P. et al. Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J. Immunol. 186, 2672–2680 (2011).
Google Scholar
Zheng, M. et al. TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in ankylosing spondylitis. EBioMedicine 47, 414–426 (2019).
Google Scholar
Duchmann, R. et al. HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis. Scand. J. Immunol. 43, 101–108 (1996).
Google Scholar
Dulphy, N. et al. Common intra-articular T cell expansions in patients with reactive arthritis: identical beta-chain junctional sequences and cytotoxicity toward HLA-B27. J. Immunol. 162, 3830–3839 (1999).
Google Scholar
May, E. et al. TCRB junctional regions from HLA-B27-restricted T cells and HLA-B27 binding peptides display conserved hydropathy profiles in the absence of primary sequence homology. Int. Immunol. 8, 1815–1823 (1996).
Google Scholar
Evans, D. M. et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat. Genet. 42, 123–127 (2010).
Google Scholar
York, I. A. et al. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc. Natl Acad. Sci. USA 103, 9202–9207 (2006).
Google Scholar
York, I. A. et al. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues. Nat. Immunol. 3, 1177–1184 (2002).
Google Scholar
Martin-Esteban, A., Gomez-Molina, P., Sanz-Bravo, A. & Lopez de Castro, J. A. Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands. J. Biol. Chem. 289, 3978–3990 (2014).
Google Scholar
Diaz-Pena, R., Lopez-Vazquez, A. & Larrea, L. Old and new HLA associations with ankylosing spondylitis. Tissue Antigens 80, 205–213 (2012).
Google Scholar
Colmegna, I., Cuchacovich, R. & Espinoza, L. R. HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. Clin. Microbiol. Rev. 17, 348–369 (2004).
Google Scholar
Ebringer, A., Rashid, T., Tiwana, H. & Wilson, C. A possible link between Crohn’s disease and ankyloisng spondylitis via Klebsiella infections. Clin. Rheumatol. 26, 289–297 (2007).
Google Scholar
Rashid, T., Wilson, C. & Ebringer, A. The link between ankylosing spondylitis, Crohn’s disease, Klebsiella, and starch consumption. Clin. Dev. Immunol. 2013, 872632 (2013).
Stewart-Jones, G. B. E. et al. Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705. Eur. J. Immunol. 35, 341–351 (2005).
Google Scholar
Hulsmeyer, M. et al. HLA-B27 subtypes differentially associated with disease exhibited subtle structural alterations. J. Biol. Chem. 277, 47844–47853 (2002).
Google Scholar
Lim Kam Sian, T. C. C. et al. Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation. J. Biol. Chem. 294, 20185–20195 (2019).
Google Scholar
Cole, D. K. et al. Human TCR-binding affinity is governed by MHC class restriction. J. Immunol. 178, 5727–5734 (2007).
Google Scholar
Petersen, J. et al. Diverse T cell receptor gene usage in HLA-DQ8-associated celiac disease converges into a consensus binding solution. Structure 24, 1643–1657 (2016).
Google Scholar
Yang, X. et al. Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J. Biol. Chem. 292, 18618–18627 (2017).
Google Scholar
May, E. et al. Conserved TCR beta chain usage in reactive arthrits; evidence for selection by a putative HLA-B27-associated autoantigen. Tissue Antigens 60, 299–308 (2002).
Google Scholar
Broughton, S. E. et al. Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. Immunity 37, 611–621 (2012).
Google Scholar
Venturi, V. et al. Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc. Natl Acad. Sci. USA 103, 18691–18696 (2006).
Google Scholar
Roldan, E. Q. et al. Different TCRBV genes generate biased pattern of V-D-J diversity in human T cells. Immunogenetics 41, 91–100 (1995).
Google Scholar
Schittenhelm, R. B. et al. Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes. Arthritis Rheumatol. 67, 702–713 (2015).
Google Scholar
Barnea, E. et al. The human leukocyte antigen (HLA)-B27 peptidome in vivo, in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of Erap1 deletion. Mol. Cell Proteomics 16, 642–662 (2017).
Google Scholar
Garcia-Medal, N. et al. Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1). Mol. Cell. Proteomics 13, 3367–3380 (2014).
Google Scholar
Schittenhelm, R. B. et al. Human leukocyte antigen (HLA)-B27 allotype-specific binding and candidate arthritogenic peptides revealed through heuristic clustering of data-independent acquisition mass spectrometry (DIA-MS) data. Mol. Cell. Proteomics 15, 1867–1876 (2016).
Google Scholar
Chagin, A. S. & Sävendahl, L. GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. J. Clin. Endocrinol. Metab. 92, 4873–4877 (2007).
Google Scholar
Heino, T. J., Chagin, A. S. & Sävendahl, L. The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone. J. Endocrinol. 197, R1–R6 (2008).
Google Scholar
Gautam, P. et al. Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nat. Commun. 28, 5675 (2021).
Google Scholar
Cole, D. K. et al. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. J. Clin. Invest. 26, 2191–2204 (2016).
Google Scholar
Petersen, J. et al. T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease. Nat. Struct. Mol. Biol. 27, 49–61 (2020).
Google Scholar
Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for spondyloarthritis/HLA-B27-associated anterior uvetis. Am. J. Ophthalmol. 228, 117–125 (2021).
Google Scholar
Rudwaleit, M. et al. The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann. Rheum. Dis. 68, 777–783 (2009).
Google Scholar
Jabs, D. A. et al. Standardization of uveitis nonmenclature for reporting clinical data. Results of the first international workshop. Am. J. Ophthalmol. 140, 509–516 (2005).
Google Scholar
Hassman, L. M. et al. Clinicomolecular identification of conserved and individualized features of granulomatous uveitis. Ophthalmol. Sci. https://doi.org/10.1016/j.xops.2021.100010 (2021).
Google Scholar
Pogorelyy, M. V. et al. Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. PLoS Comput. Biol. 13, e1005572 (2017).
Google Scholar
Shugay, M. et al. Towards error-free profiling of immune repertoires. Nat. Methods 11, 653–655 (2014).
Google Scholar
Bolotin, D. A. et al. MiXCR: software for comprehensive adaptive immunity profiling. Nat. Methods 12, 380–381 (2015).
Google Scholar
Bowness, P., Allen, R. L. & McMichael, A. J. Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27. Eur. J. Immunol. 24, 2357–2363 (1994).
Google Scholar
Lybarger, L. et al. Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide. J. Biol. Chem. 278, 27105–27111 (2003).
Google Scholar
Birnbaum, M. E. et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157, 1073–1087 (2014).
Google Scholar
Garboczi, D. N. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134–141 (1996).
Google Scholar
Aricescu, A. R., Lu, W. & Jones, E. Y. A time- and cost-efficient system for high-level protein production in mammalian cells. Acta Crystallogr. D 62, 1243–1250 (2006).
Google Scholar
Ellis, S. A., Taylor, C. & McMichael, A. Recognition of HLA-B27 and related antigen by a monoclonal antibody. Hum. Immunol. 5, 49–59 (1982).
Garboczi, D. N., Hung, D. T. & Wiley, D. C. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc. Natl Acad. Sci. USA 89, 3429–3433 (1992).
Google Scholar
Emsley, P. et al. Features and development of COOT. Acta Crystallogr. D 66, 486–501 (2010).
Google Scholar
Liebschner, D. et al. Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr. D 75, 861–877 (2019).
Google Scholar