Squair, J. W., Phillips, A. A., Harmon, M. & Krassioukov, A. V. Emergency management of autonomic dysreflexia with neurologic complications. Can. Med. Assoc. J. 188, 1100–1103 (2016).
Google Scholar
Readdy, W. J. et al. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J. Neurosurg. Spine 23, 574–580 (2015).
Google Scholar
Inoue, T., Manley, G. T., Patel, N. & Whetstone, W. D. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J. Neurotrauma 31, 284–291 (2014).
Google Scholar
Squair, J. W. et al. Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury. Neurology 89, 1660–1667 (2017).
Google Scholar
Squair, J. W. et al. Empirical targets for acute haemodynamic management of individuals with spinal cord injury. Neurology 93, e1205–e1211 (2019).
Google Scholar
Cragg, J. J., Noonan, V. K., Krassioukov, A. & Borisoff, J. Cardiovascular disease and spinal cord injury: results from a national population health survey. Neurology 81, 723–728 (2013).
Google Scholar
Wu, J.-C. et al. Increased risk of stroke after spinal cord injury: a nationwide 4-year follow-up cohort study. Neurology 78, 1051–1057 (2012).
Google Scholar
Illman, A., Stiller, K. & Williams, M. The prevalence of orthostatic hypotension during physiotherapy treatment in patients with an acute spinal cord injury. Spinal Cord 38, 741–747 (2000).
Google Scholar
Carlozzi, N. E. et al. Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: development of a conceptual model. Arch. Phys. Med. Rehabil. 94, 1721–1730 (2013).
Google Scholar
Furlan, J. C., Fehlings, M. G., Shannon, P., Norenberg, M. D. & Krassioukov, A. V. Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injury. J. Neurotrauma 20, 1351–1363 (2003).
Google Scholar
Capogrosso, M. et al. A brain-spine interface alleviating gait deficits after spinal cord injury in primates. Nature 539, 284–288 (2016).
Google Scholar
Wagner, F. B. et al. Targeted neurotechnology restores walking in humans with spinal cord injury. Nature 563, 65–71 (2018).
Google Scholar
Saadoun, S., Chen, S. & Papadopoulos, M. C. Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury. J. Neurol. Neurosurg. Psychiatry 88, 452–453 (2016).
Google Scholar
Vale, F. L., Burns, J., Jackson, A. B. & Hadley, M. N. Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J. Neurosurg. 87, 239–246 (1997).
Google Scholar
Rawlings, A. M. et al. Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. Neurology 91, e759–e768 (2018).
Google Scholar
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N. & Warburton, D. E. R. Baroreflex function after spinal cord injury. J. Neurotrauma 29, 2431–2445 (2012).
Google Scholar
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N. & Warburton, D. E. R. Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine. J. Appl. Physiol. 116, 645–653 (2014).
Google Scholar
Courtine, G. et al. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat. Neurosci. 12, 1333–1342 (2009).
Google Scholar
Angeli, C. A. et al. Recovery of over-ground walking after chronic motor complete spinal cord injury. N. Engl. J. Med. 379, 1244–1250 (2018).
Google Scholar
Gill, M. L. et al. Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia. Nat. Med. 24, 1677–1682 (2018).
Google Scholar
Wenger, N. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nat. Med. 22, 138–145 (2016).
Google Scholar
West, C. R. et al. Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury. JAMA Neurol. 75, 630–632 (2018).
Google Scholar
Harkema, S. J. et al. Epidural spinal cord stimulation training and sustained recovery of cardiovascular function in individuals with chronic cervical spinal cord injury. JAMA Neurol. 75, 1569–1571 (2018).
Google Scholar
Harkema, S. J. et al. Normalization of blood pressure with spinal cord epidural stimulation after severe spinal cord injury. Front. Hum. Neurosci. 12, 83 (2018).
Google Scholar
Darrow, D. et al. Epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal cord injury. J. Neurotrauma 36, 2325–2336 (2019).
Google Scholar
Grimm, D. et al. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J. Virol. 82, 5887–5911 (2008).
Google Scholar
Witten, I. B. et al. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron 72, 721–733 (2011).
Google Scholar
Tomer, R., Ye, L., Hsueh, B. & Deisseroth, K. Advanced CLARITY for rapid and high-resolution imaging of intact tissues. Nat. Protocols 9, 1682–1697 (2014).
Google Scholar
Strack, A. M., Sawyer, W. B., Marubio, L. M. & Loewy, A. D. Spinal origin of sympathetic preganglionic neurons in the rat. Brain Res. 455, 187–191 (1988).
Google Scholar
Capogrosso, M. et al. A computational model for epidural electrical stimulation of spinal sensorimotor circuits. J. Neurosci. 33, 19326–19340 (2013).
Google Scholar
Gradinaru, V., Thompson, K. R. & Deisseroth, K. eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol. 36, 129–139 (2008).
Google Scholar
Phillips, A. A., Elliott, S. L., Zheng, M. M. Z. & Krassioukov, A. V. Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury. J. Neurotrauma 32, 392–396 (2015).
Google Scholar
Beauparlant, J. et al. Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury. Brain 136, 3347–3361 (2013).
Google Scholar
Minev, I. R. et al. Biomaterials. Electronic dura mater for long-term multimodal neural interfaces. Science 347, 159–163 (2015).
Google Scholar
Formento, E. et al. Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury. Nat. Neurosci. 21, 1728–1741 (2018).
Google Scholar
Cornwell, W. K. III et al. Restoration of pulsatile flow reduces sympathetic nerve activity among individuals with continuous-flow left ventricular assist devices. Circulation 132, 2316–2322 (2015).
Google Scholar
Purohit, S. N., Cornwell, W. K. III, Pal, J. D., Lindenfeld, J. & Ambardekar, A. V. Living without a pulse: the vascular implications of continuous-flow left ventricular assist devices. Circ. Heart Fail. 11, e004670 (2018).
Google Scholar
Cheng, A., Williamitis, C. A. & Slaughter, M. S. Comparison of continuous-flow and pulsatile-flow left ventricular assist devices: is there an advantage to pulsatility? Ann. Cardiothorac. Surg. 3, 573–581 (2014).
Google Scholar
Saleem, S. et al. Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. Am. J. Physiol. Heart Circ. Physiol. 314, H1108–H1114 (2018).
Google Scholar
Phillips, A. A., Warburton, D. E. R., Ainslie, P. N. & Krassioukov, A. V. Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride. J. Cereb. Blood Flow Metab. 34, 794–801 (2014).
Google Scholar
Courtine, G. & Bloch, J. Defining ecological strategies in neuroprosthetics. Neuron 86, 29–33 (2015).
Google Scholar
Phillips, A. A. & Krassioukov, A. V. Contemporary cardiovascular concerns after spinal cord injury: mechanisms, maladaptations, and management. J. Neurotrauma 32, 1927–1942 (2015).
Google Scholar
Phillips, A. A. & Krassioukov, A. V. in Neurological Aspects of Spinal Cord Injury (eds Weidner, N. et al.) 325–361 (Springer International Publishing, 2017).
Richardson, R. R., Cerullo, L. J. & Meyer, P. R. Autonomic hyper-reflexia modulated by percutaneous epidural neurostimulation: a preliminary report. Neurosurgery 4, 517–520 (1979).
Google Scholar
Ramsey, J. B. G. et al. Care of rats with complete high-thoracic spinal cord injury. J. Neurotrauma 27, 1709–1722 (2010).
Google Scholar
Anderson, M. A. et al. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature 561, 396–400 (2018).
Google Scholar
Squair, J. W. et al. High thoracic contusion model for the investigation of cardiovascular function after spinal cord injury. J. Neurotrauma 34, 671–684 (2016).
Google Scholar
Asboth, L. et al. Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nat. Neurosci. 21, 576–588 (2018).
Google Scholar
Scheff, S. W., Rabchevsky, A. G., Fugaccia, I., Main, J. A. & Lumpp, J. E., Jr. Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J. Neurotrauma 20, 179–193 (2003).
Google Scholar
van den Brand, R. et al. Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science 336, 1182–1185 (2012).
Google Scholar
Krassioukov, A. V. & Weaver, L. C. Connections between the pontine reticular formation and rostral ventrolateral medulla. Am. J. Physiol. 265, H1386–H1392 (1993).
Google Scholar
Ueno, M., Ueno-Nakamura, Y., Niehaus, J., Popovich, P. G. & Yoshida, Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat. Neurosci. 19, 784–787 (2016).
Google Scholar
Sundt, D., Gamper, N. & Jaffe, D. B. Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J. Neurophysiol. 114, 3140–3153 (2015).
Google Scholar
McIntyre, C. C. & Grill, W. M. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. J. Neurophysiol. 88, 1592–1604 (2002).
Google Scholar
Pan, C. et al. Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat. Methods 13, 859–867 (2016).
Google Scholar
Lee, E. et al. ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging. Sci. Rep. 6, 18631 (2016).
Google Scholar
Bria, A. & Iannello, G. TeraStitcher – a tool for fast automatic 3D-stitching of teravoxel-sized microscopy images. BMC Bioinformatics 13, 316 (2012).
Google Scholar
Rizk, A. et al. Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh. Nat. Protocols 9, 586–596 (2014).
Google Scholar
Kirshblum, S. C. et al. International standards for neurological classification of spinal cord injury (revised 2011). J. Spinal Cord Med. 34, 535–546 (2011).
Google Scholar
Bogert, L. W. J. & van Lieshout, J. J. Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp. Physiol. 90, 437–446 (2005).
Google Scholar
Jansen, J. R. et al. A comparison of cardiac output derived from the arterial pressure wave against thermodilution in cardiac surgery patients. Br. J. Anaesth. 87, 212–222 (2001).
Google Scholar
Westerhof, B. E., Gisolf, J., Stok, W. J., Wesseling, K. H. & Karemaker, J. M. Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set. J. Hypertens. 22, 1371–1380 (2004).
Google Scholar
Wieling, W., Ganzeboom, K. S. & Saul, J. P. Reflex syncope in children and adolescents. Heart 90, 1094–1100 (2004).
Google Scholar
Whinnett, Z. I. et al. Multicenter randomized controlled crossover trial comparing haemodynamic optimization against echocardiographic optimization of av and VV delay of cardiac resynchronization therapy: the BRAVO trial. JACC Cardiovasc. Imaging 12, 1407–1416 (2019).
Google Scholar
Notay, K. et al. Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans. J. Appl. Physiol. 121, 1065–1073 (2016).
Google Scholar
Incognito, A. V. et al. Evidence for differential control of muscle sympathetic single units during mild sympathoexcitation in young, healthy humans. Am. J. Physiol. Heart Circ. Physiol. 316, H13–H23 (2019).
Google Scholar
Wallin, B. G. et al. Sympathetic single axonal discharge after spinal cord injury in humans: activity at rest and after bladder stimulation. Spinal Cord 52, 434–438 (2014).
Google Scholar
Incognito, A. V. et al. Pharmacological assessment of the arterial baroreflex in a young healthy obese male with extremely low baseline muscle sympathetic nerve activity. Clin. Auton. Res. 28, 593–595 (2018).
Google Scholar